Round 12 was the final round of the Tyrrells Premier 15s before the break for the start of the Women's Six Nations.
Harlequins Women will go into the two-month break top of the table after their emphatic win over Darlington Mowden Park Sharks.
Jess Breach helped herself to five tries and Heather Cowell to four as Quins won 68-0 as they scored 12 tries in total over the north east outfit.
Saracens Women sit just behind Harlequins as they continued their perfect record so far this season with 11 wins from 11 at Worcester Warriors Women [26-48], despite having to play parts of the game without a full XV.
Red Roses forwards Poppy Cleall and Hannah Botterman both scored a brace as Sarries ran in eight tries overall, but Worcester got a try bonus-point for their four scores.
Wasps FC Ladies managed to come out on top in a battling performance against Bristol Bears Women in a 34-20 victory.
England's Claudia Macdonald and Abby Dow were among the try scorers as the London side came out on top as it keeps them in the hunt for the play-off places.
Loughborough Lightning kept up their chase on the top two as they secured a bonus-point win [5-74] at Firwood Waterloo Ladies.
England captain Sarah Hunter crossed twice along with fellow Red Roses Emily Scarratt and Katy Daley-Mclean going over.
Gloucester-Hartpury Women remain in the final play-off place of fourth as they secured a [0-20] bonus-point win over Richmond Women in south west London.
England's Natasha Hunt and Kelly Smith scored tries as the West Country outfit scored their four tries in the first half and the second half then remained scoreless.